One-time college pals Veronica (Sandra Oh) and Ashley (Anne Heche) run into each other at a party. The women, now in their forties and having not seen each other since school, find that their lives have taken radically different paths. Ashley is barely scraping by as a painter of politically charged canvases, while Veronica is married to a wealthy businessman who's about to profit hugely off yet another US-led war in the Middle East. Within minutes of their reunion, a rivalry is revived, old wounds are torn open, and a Manhattan stairwell becomes home to a woman-on-woman brawl the likes of which are seldom seen outside of martial-arts epics. And now the gloves are off. Over the course of five years and three bloody, bone-crushing rounds, Catfight's formidable adversaries will lose everything they cherish, and rail furiously as their fortunes are subject to wild reversals.