Marmaduke, the world's most lovable Great Dane, leaps from comic strip fame to big screen stardom. The super-sized, ultra-awkward lap dog is living the good life with the Winslow family, including beleaguered dad Phil (Lee Pace), Phil's wife Debbie (Judy Greer), their three children, and feline pal Carlos. But when Phil uproots the clan from Kansas to California, Marmaduke finds his life turned upside-down. He must navigate the volatile Mutts vs. Pedigrees turf wars, woo the purebred of his dreams, somehow triumph in a canine surfing contest and overcome a fall from grace from his new four-legged friends and his much put-upon family.