OH LUCY! follows Setsuko, (Terajima, DEAR ETRANGER, STAR SAND, AKAME 48 WATERFALLS), a single, emotionally unfulfilled woman, seemingly stuck with a drab, meaningless life in Tokyo. At least until she's convinced by her niece, Mika (Shioli Kutsuna, THE OUTSIDER, DEADPOOL 2), to enroll in an unorthodox English class that requires her to wear a blonde wig and take on an American alter ego named 'Lucy.' The new identity awakens something dormant in Setsuko, and she quickly develops romantic feelings for her American instructor, John (Josh Hartnett, PENNY DREADFUL). When John suddenly disappears from class and Setsuko learns he and Mika were in fact dating, she enlists the help of her sister, Ayako (Kaho Minami, ANGEL DUST, KABUKICHO LOVE HOTEL), and flies halfway across the world to the outskirts of Southern California in search of the runaway couple. And in a brave new world of tattoo parlors and seedy motels, family ties and past lives are tested as Setsuko struggles to preserve the dream and promise of 'Lucy.'