South Park: Bigger, Longer & Uncut

George Timothy Clooney was born on May 6, 1961, in Lexington, Kentucky, to Nina Bruce (née Warren), a former beauty pageant queen, and Nick Clooney, a former anchorman and television host (who was also the brother of singer Rosemary Clooney). He has Irish, English, and German ancestry. Clooney spent most of this youth in Ohio and Kentucky, and graduated from Augusta High School. He was very active in sports such as basketball and baseball, and tried out for the Cincinnati Reds, but was not offered a contract. After his cousin, Miguel Ferrer, got him a small part in a feature film, Clooney began to pursue acting. His first major role was on the sitcom E/R (1984) as "Dr. Doug Ross". More roles soon followed, including "George Burnett", the handsome handyman on The Facts of Life (1979); "Booker Brooks", a supervisor on Roseanne (1988); and "Detective James Falconer" on Sisters (1991). Clooney had his breakthrough when he was cast as "Dr. Doug Ross" on the award-winning drama series, ER (1994), opposite Anthony Edwards, Noah Wyle, and Julianna Margulies. While filming "ER", Clooney starred in a number of high profile film roles, such as Robert Rodriguez's From Dusk Till Dawn (1996), and One Fine Day (1996), opposite Michelle Pfeiffer. In 1997, Clooney took on the role of "Batman" in Joel Schumacher's Batman & Robin (1997). The film was a moderate success in the box office, but was slammed by critics, notably for the nipple-laden Bat suit. Clooney went on to star in Steven Soderbergh's Out of Sight (1998), Terrence Malick's The Thin Red Line (1998), and David O. Russell's Three Kings (1999). In 1999, Clooney left "ER" (though he would return for the season finale) and appeared in a number of films, including O Brother, Where Art Thou? (2000), The Perfect Storm (2000), and Ocean's Eleven (2001). Collaborating once again with Steven Soderbergh, "Ocean's Eleven" received critical acclaim, earned more than $450 million at the box office, and spawned two sequels: Ocean's Twelve (2004) and Ocean's Thirteen (2007). In 2002, Clooney made his directorial debut with Confessions of a Dangerous Mind (2002), an adaptation of TV producer Chuck Barris's autobiography. This was the first film under the banner of "Section Eight Productions", a production company he founded with Steven Soderbergh. The company also produced many acclaimed films, including Far from Heaven (2002), Syriana (2005), A Scanner Darkly (2006), and Good Night, and Good Luck. (2005). Clooney won his first Oscar for Best Supporting Actor in "Syriana", and was nominated for Best Director and Best Original Screenplay for "Good Night, and Good Luck". In 2006, "Section Eight" was shut down so that Soderbergh could concentrate on directing, and Clooney founded a new production company, "Smokehouse Productions", with his friend and long-time business partner, Grant Heslov. Clooney went on to produce and star in Michael Clayton (2007) (which earned him an Oscar nomination for Best Actor), directed and starred in Leatherheads (2008), and took leading roles in Burn After Reading (2008), The Men Who Stare at Goats (2009), Fantastic Mr. Fox (2009), and Jason Reitman's Up in the Air (2009). Clooney received critical acclaim for his performance in "Up in the Air" and was nominated for several awards, including a Golden Globe and Academy Award. He didn't win that year, but took home both Best Actor awards (as well as countless nominations) for his role as a father who finds out his wife was unfaithful as she lay in a coma in Alexander Payne's The Descendants (2011). Throughout his career, Clooney has been heralded for his political activism and humanitarian work. He has served as one of the "United Nations Messengers of Peace" since 2008, has been an advocate for the Darfur conflict, and organized the "Hope for Haiti" telethon, to raise money for the victims of the 2010 earthquake. In March of 2012, Clooney was arrested for civil disobedience while protesting at the Sudanese embassy in Washington, D.C. Clooney was married to actress Talia Balsam, from 1989 until 1993. After their divorce, he swore he would never marry again. Michelle Pfeiffer and Nicole Kidman bet him $10,000 that he would have children by the age of 40, and sent him a check shortly after his birthday. Clooney returned the funds and bet double or nothing he wouldn't have children by the age of 50. Although he has remained a consummate bachelor, Clooney has had many highly publicized relationships, including with former WWE wrestler Stacy Keibler. In 2014, he married lawyer and activist Amal Clooney.

Brent Spiner, whose primary claim to fame is his portrayal of the beloved android Data on the television series Star Trek: The Next Generation (1987), was born and raised in Houston, Texas. His parents, Sylvia (Schwartz) and Jack Spiner, owned and operated a furniture store, and were both from Jewish immigrant families (from Austria, Hungary, and Russia). Jack died of kidney failure at age 29, when Brent was 10 months old. When he was 6 years old, his mother married Sol Mintz, who adopted Brent and his older brother Ron. Although his mother divorced Mintz after 7 years of marriage, Brent retained his adopted father's last name until 1975, when he took back his birth name. Spiner first began pursuing his interest in acting while in high school. There his inspirational drama teacher, Cecil Pickett, gave a great start to the careers of a remarkable group of aspiring young actors (and directors), including Spiner, Cindy Pickett (Cecil's daughter), Randy Quaid, Dennis Quaid, Trey Wilson, Robert Wuhl and Thomas Schlamme, all of whom later attained success in Hollywood. After graduation, Spiner followed his mentor to the University of Houston and other local colleges, while also launching his professional acting career in theater (The Houston Music Theater and other regional theater) and in film (My Sweet Charlie (1970), which was shot on location in Texas). After a couple of false starts in New York and Hollywood, Spiner eventually established himself as a stage actor in New York, appearing in a number of off-Broadway and Broadway plays, such as "A History of the American Film" (1978), "Leave It to Beaver is Dead" (1979), "Sunday in the Park with George" (1984), and "Big River: The Adventures of Huckleberry Finn" (1985). While in New York, he had a bit part in Woody Allen's Stardust Memories (1980) and starred in an independent film called Rent Control (1981). The play "Little Shop of Horrors "brought Spiner to Los Angeles in 1984, where he eventually took up permanent residence. In 1986, after a number of character parts in television series and movies, such as Robert Kennedy and His Times (1985), Crime of Innocence (1985), Manhunt for Claude Dallas (1986), and Family Sins (1987), Spiner snagged the role that would bring him international fame: Data, the endearing android, whom Spiner played "by tapping into his inner child." Star Trek: The Next Generation (1987), the sequel to the original television series Star Trek: The Original Series (1966), became hugely popular, moving to the big screen for four films (so far) after its 7-year run on television. Aside from these films, Spiner has made cameo appearances in a number of films directed by his friend and old schoolmate Thomas Schlamme, such as Miss Firecracker (1989), Crazy from the Heart (1991), and Kingfish: A Story of Huey P. Long (1995), and has appeared in small roles in more recent films, such as Dude, Where's My Car? (2000) and The Master of Disguise (2002). Arguably his most popular film portrayal was Dr. Brakish Okun in Independence Day (1996), a role that elicited his unique eccentricity and sense of humor. He reprised the character in the sequel, Independence Day: Resurgence (2016).

Dave Foley dropped out of an alternative high school to do stand-up comedy. He met Kevin McDonald at an improv class and, while employed as movie ushers, they began working as a comedy team. In 1984 they merged with another team to form "The Kids in the Hall". Foley made his film debut at 22 as the lead in the Canadian film High Stakes (1986).

Trey was born in Conifer, Colorado, on October 19, 1969 to Randy Parker, a geologist, and Sharon Parker, an insurance broker. He has an older sister, Shelley Parker. He met Matt Stone (co-creator of South Park (1997)) while attending the University of Colorado in Boulder, where he had a double major of music and Japanese. While at UCB he wrote, directed and starred in Cannibal! The Musical (1993) (aka "Cannibal: The Musical!") based on a true episode in Colorado's history. After graduation from UCB (rumors that he didn't due to skipping classes to work on the movie are false), he and Stone were asked by then-FoxLab executive Brian Graden to create an animated Christmas card for his friends and family. The now infamous short, titled The Spirit of Christmas (1995), led to South Park (1997).