Based on Patrick Dewitt's acclaimed novel of the same name, follows two brothers - Eli and Charlie Sisters - who are hired to kill a prospector who has stolen from their boss. The story, a genre-hybrid with comedic elements, takes place in Oregon in 1851.

  • 2 hr 1 minChildren under 17 may not attend R-rated movies unaccompanied by a parent or adult guardian. Children ages 6 and under are not allowed at R-rated movies after 6pm.RHDSD
  • Sep 21, 2018
  • Drama

More Trailers and Videos for The Sisters Brothers

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3 Upcoming John C. Reilly Films

Reilly is a talented and well-rounded actor, comedian and voice over artist — and this year alone, he has three films hitting theatres. Read on to learn more and get your tickets at AMC.

Cast & Crew

  • Joaquin PhoenixActor

  • John C. ReillyActor

  • Jake GyllenhaalActor

  • Riz AhmedActor

  • Rutger HauerActor

  • Rebecca RootActor

  • Jacques AudiardDirector

  • Megan EllisonProducer

  • Alison DickeyProducer

  • Gregoire SorlatProducer