As part of a routine mission, a unit of National Guard soldiers stop at a New Mexican outpost only to find the isolated research camp mysteriously deserted. After spotting a distress signal in a distant mountain range, the team decides to commence a search and rescue mission into the hills. Little do they know that these are the very hills that the ill-fated Carter family once visited, and that a tribe of cannabalistic mutants lies in wait. And this time, there is an even larger force of evil at work that is intent on the soldiers' very destruction.